Manchester United started the 2024-25 Premier League campaign with a narrow 1-0 victory over Fulham at Old Trafford on Friday night courtesy.
Summer signing Joshua Zirkzee netted the winner, but they also suffered an injury scare and could be handed a massive blow going forward.
Matthijs de Ligt replaced Harry Maguire in the 81st minute, and Sky Sports posted on their live commentary page that he was limping and holding the back of his right leg as he went off.
An injury to French centre-back Leny Yoro in pre-season forced the Red Devils to quickly wrap up a deal for the Netherlands international.
However, their options at the back could become thinner if Maguire is unavailable for selection.
Luke Shaw is already out of action until next month, while Tyrell Malacia is yet to return to first-team training after missing the whole of last season.
Diogo Dalot filled in at left-back against Fulham, while summer arrival Noussair Mazraoui made his debut at right-back before he was replaced by Jonny Evans.
Man United have three centre-backs available if Maguire has picked up a serious knock, but starting another campaign with injuries to key players is the last thing Erik ten Hag wants.
The Red Devils return to action next Saturday with a trip to face Brighton & Hove Albion, and they will be keen to make it back-to-back Premier League victories.
Their win tonight was far from impressive after they left it late against the London club.
They got the job done in the end, and Ten Hag will hope that keeps happening as he looks to challenge for the Premier League title this term.