The news is a massive blow for United and the Danish centre-forward, who has been in incredible form over the past few weeks.
He will miss the Manchester derby next weekend. Manchester City welcome United to the Etihad Stadium, looking to maintain their title charge.
The Red Devils have a chance to spoil their party, but their odds of winning just took a massive hit, with the young striker set to miss the game.
Hojlund has netted in six successive Premier League matches following his brace against Luton Town last weekend.
He has bounced back from a turbulent first half of the season and has now bagged seven goals and two assists in 20 league appearances for the Red Devils.
However, the former Atalanta centre-forward will miss this weekend’s match against Fulham and the midweek FA Cup clash with Nottingham Forest.
United also have fixtures against Everton and Sheffield United before the March international break.
Hojlund will hope to be back on the pitch when United lock horns with the Blades. He will be desperate to continue his terrific run of form.
With his brace against the Hatters, the 21-year-old became the youngest player to score in six consecutive Premier League games, breaking Joe Willock’s record by a few days.
After struggling to find the back of the net in the league, the tides turned when the Norwegian attacker bagged a late winner against Aston Villa on Boxing Day.
He continued his goalscoring exploits against Tottenham Hotspur, Wolverhampton Wanderers, West Ham United and Villa again before the Luton clash.
Hojlund is beginning to deliver on the promise of his potential and will hope to bag more goals when he returns from this setback.